Enabling Oral Delivery of any Insoluble Drug
VeraMorph's Platform Technology
Disintegrating Polymeric Oral Dosages (DPODs)
DPODs create an optimal combination of high drug stability, fast dissolution rate, and prolonged levels of high supersaturation in an oral dosage form capable of higher drug loading than current formulations.
Solid State Stability
We control the chemistry of our DPODs to spontaneously transform an API into nanocrystals within the three-dimensional covalently cross-linked polymer network.
Hydrogels decompose into solubility enhancing polymers while releasing nanocrystalline API, which improve the dissolution rate and solubility above levels that either can achieve independently.
High Drug Loading
Hydrogels are initially composed by as little as 10% (by volume) polymer and can be made to swell to further increase the remaining volume of nanopores to load with API.
See more details in our peer-reviewed publication in the journal Small.
In addition to their versatility and simplicity, DPODs are capable of improving the solubility and controlling the release profile through their polymer chemistry before and after decomposing upon ingestion. The result is a stable dosage form that achieves immediate release up to high levels of supersaturation in physiologically relevant media. These release profiles are consistent despite varying from 30% to 60% by weight of drug substance.
The broad compatibility of DPODs is being leveraged to develop a pipeline of highly differentiated oral reformulations and establish partnerships to translate more effective lead compounds for drug targets
A Platform Technology
Current formulation techniques (e.g., nanocrystals, amorphous dispersions, and lipid formulations) to improve drug solubility are effective for compounds with specific combinations of physical properties (e.g., melt temperature and lipophilicity or LogP). In many cases, a given API falls outside the compatibility region of current formulations, which hinders the development of potentially therapeutic compounds.
In contrast, DPODs can serve as an effective delivery vehicle for essentially any compound due to their chemical versatility. As a result, DPODs can dramatically simplify the formulation development process and expand the number of drugs as lead compounds. Their robust mechanical properties make DPODs uniquely capable of transforming lipid formulations and liquid APIs into oral solid dosages. Further, the solution processing utilized for drug loading is a preferred approach for handling highly potent drugs (HPAPIs) as opposed to powder processing.